Norpega-NT Tablets are a pharmaceutical multimodal formulation designed for effective management of peripheral neuropathic pain. The dual-action combination of pregabalin and nortriptyline targets both peripheral nerve hyperexcitability and central pain modulation, providing comprehensive relief in chronic neuropathic pain conditions while also improving sleep quality and overall patient comfort.
Norpega-NT Tablets are a pharmaceutical multimodal formulation designed for effective management of peripheral neuropathic pain. The dual-action combination of pregabalin and nortriptyline targets both peripheral nerve hyperexcitability and central pain modulation, providing comprehensive relief in chronic neuropathic pain conditions while also improving sleep quality and overall patient comfort.
Peripheral neuropathic pain Diabetic neuropathy Post-herpetic neuralgia (PHN) Chronic low back pain (CLBP) Radiculopathy and nerve root pain Neuropathic pain associated with sleep disturbances
As directed by the physician
Pregabalin – 50 mg Nortriptyline – 10 mg
Pregabalin (50 mg) Modulates voltage-gated calcium channels Reduces release of excitatory neurotransmitters Decreases abnormal peripheral nerve signaling Relieves peripheral and diabetic neuropathic pain Nortriptyline (10 mg) Increases norepinephrine activity in the central nervous system Enhances descending inhibitory pain pathways Improves sleep quality and central pain control Combined Effect: The dual-pathway mechanism provides comprehensive neuropathic pain relief by simultaneously reducing peripheral nerve hyperactivity and strengthening central pain inhibition, resulting in sustained analgesia and improved quality of life.
